扎根科研,积极投入,广泛合作,专心做事

 
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卞兆祥

基本情况

姓  名: 卞兆祥

职  称: 教授

职务:云南民族大学-香港浸会大学传统天然药物研发联合实验室主任

学  历: 博士研究生

学  位: 博士

工作单位:香港浸会大学

   卞兆祥,香港浸会大学协理副校长、中医药学院副院長及临床部主任;中医药、中药药理、内脏痛及新药研制专家。卞教授1988年毕业于南京中医药大学,获中 医学学士学位,1991年获北京中医药大学硕士学位,1994年于广州中医药大学获医学博士学位。毕业后于广州中医药大学从事科研、临床及教学工作。曾获 得国家科技进步二等奖等多项科研奖励。

    2001年加入香港浸会大学中医药学院后,先后承担包括来自香港研究资助局(RGC)、香港 食物环境卫生福利局、香港赛马会中药研究院基金项目在内的多项研究工作。卞教授长期从事中西医结合临床及临床基础研究,主要的研究方向为内脏痛觉过敏和肠道动力障碍与抑郁的相关机制;心理应激对肠道疾病的影响;中医药治疗胃肠疾病的疗效及安全性评价及新药开发;以及中草药临床研究规范化。是优良中医药临床研究报告规范的积极参与者;与香港中文大学合作研究的中药复方获得中国药品与食品监督管理局的新药临床证书;相关研究已在国内国际发表论文二百余篇,SCI 收录文章100余篇,出版专著3部,参编专著五部,申报中国及美国专利80余项,现时获得授权美国专利6项,中国专利5项。

教育经历

学士:南京中医药大学,1988年

硕士:北京中医药大学,1991年

博士:广州中医药大学,1994年

工作经历

2014/5 - 至今,云南民族大学,云南民族大学-香港浸会大学传统天然药物研发联合实验室,教授(柔性引进)

2010/9 - 至今,天津中医药大学,荣誉教授

2001/5 - 至今,香港浸会大学,中医药学院,助理教授/副教授/教授/讲座教授

1994/7 - 2001/4,广州中医药大学,消化病所,讲师/副教授

Part I  Experimental Researches

1.Fatima S, Shi XK, Lin ZS, Chen GQ, Pan XH,  Wu CY, Ho W, Lee P,Gao HG, Zhang G, Lu AP,  Bian ZX. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. MolOncol. 2015. pii: S1574-7891(15)00167-2.

2.Chen GQ, Tang CF, Shi XK, Lin CY, Fatima.S, Pan XH, Yang DJ, Zhang G, Lu AP, Lin SH, Bian ZX. Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism. Oncotarget. 2015; 6(27):24148-62.

3.Lin CY, Zhang M, Huang T, Yang LL, Fu HB, Zhao L, Zhong LL, Mu HX, Shi XK, Leung CF, Fan BM, Jiang M, Lu AP, Zhu LX, Bian ZX*. Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice. Sci Rep. 2015; 5: 12095. doi: 10.1038/srep12095.

4.Tsang SW, Zhang H, Lin Z, Mu H, Bian ZX*. Anti-fibrotic effect of trans-resveratrol on pancreatic stellate cells. Biomed Pharmacother. 2015; 71: 91-97.

5.Tsang SW, Ip SP, Wu JC, Ng SC, Yung KK, Bian ZX*. A Chinese medicinal formulation ameliorates dextran sulfate sodium-induced experimental colitis by suppressing the activity of nuclear factor-kappaB signaling. J Ethnopharmacol. 2015; 162: 20-30.

6.Tsang SW, Bian ZX*. Anti-fibrotic and anti-tumorigenic effects of rhein, a natural anthraquinone derivative, in mammalian stellate and carcinoma cells. Phytother Res. 2015; 29(3): 407-414.

7.Qin HY, Cheng CW, Tong XD, Bian ZX*. Impact of psychological stress on irritable bowel syndrome World J Gastroentero. 2014; 20(39): 14126-14131.

8.Tsang SW, Zhang HJ, Lin CY, Xiao HT, Wong M, Shang HC, Yang ZJ, Lu AP, Yung KKL, Bian ZX*. Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis. PLoS One. 2013; 8(12): e82201.

9.Bian ZX*. Novel insights about the mechanism of visceral hypersensitivity in maternally separated rats. Neurogastroent&Motil, 2012; 24(7): 593-6.

10.Zhang XJ, Choi FFK, Yan Z, Leung FP, Tan S, Lin SH, Xu HX, Jia W, Sung JJY, Cai ZW, Bian ZX*. Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics. FEBS J., 2012, 279: 2322–2331.

11.Qin HY, Xiao HT, Leung FP, Wu JCY, Sung JJY, Xu HX, Tong XD, Bian ZX*. JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced post-inflammatory irritable bowel syndrome rats through reducing colonic EC cell hyperplasia and serotonin availability. Evid.-based Complement Altern. Med., 2012; 239638.

12.Zhang XJ, Leung FP, Hsiao WWL, Tan S, Li S, Xu HX, Sung JJY, Bian ZX*. Proteome profiling of spinal cord and DRG in rats with TNBS-induced colitis. World J Gastroenterol, 2012, 18(23): 2914-28.

13.Qin HY, Xiao HT, WU JCY, Berman BM, Sung JJ, Bian ZX*. Key factors in developing TNBS-induced Post-inflammatory Irritable Bowel Syndrome Model in Rats. World J Gastroenterol, 2012,18(20): 2481-92.

14.Tian XY, Wong WT, Sayed N, Luo J, Tsang SY, Bian ZX, Lu Y, Cheang WS, Yao X, Chen ZY, Huang Y. NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel. Pharmacol Res., 2012: 65(2): 239-46.

15.Tsang SW, Bian ZX*, Zhang XJ, Zhao M. Nerve growth factor-mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation-induced visceral hypersensitivity in rats. Eur J Pain., 2012: 16(4): 463-72.

16.Bian ZX*, Qin HY, Tian SL, Qi SD. Combined effect of early life stress and acute stress on colonic sensory and motor responses through serotonin pathways: differences between proximal and distal colon in rats. Stress, 2011, 14(4): 448-58.

17.Luo JL, Qin HY, Wong CK, Tsang SY, Huang Y, Bian ZX*. Enhanced Excitability and Down-Regulated Voltage-Gated Potassium Channels in Colonic DRG Neurons from Neonatal Maternal Separation Rats. J Pain., 2011, 12(5): 600-9.

18.Qin HY, Tian XL, Wu J, Sung JJ, Xu HX, Bian ZX*. Systematic review of animal models of post-infectious/post inflammatory irritable. J Gastroenterol., 2011, 46: 164-174.

19.Qin HY, Luo JL, Qi SD, Xu HX, Sung JJY, Bian ZX*. Visceral hypersensitivity induced by activation of Transient Receptor Potential Vanilloid Type 1 is mediated through the serotonin pathway in rat colon. Eur J Pharmacol, 2010, 647(1-3):75-83.

20.Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, Tsang SY. Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol., 2010, 224(1): 165-77.

21.Zhang M, Leung FP, Huang Y, Bian ZX*. Increased colonic motility in a rat model of irritable bowel syndrome is associated with up-regulation of L-type calcium channels in colonic smooth muscle cells. Neurogastroent&Motil, 2010, 22(5): 162-70.

22.Bian ZX*, Zhang M, Hang QB, Xu HX, Sung JJY. Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats. World J Gastroenterol, 2010, 16(7): 837-845.

23.Zhang XJ, Chen HL, Li Z, Zhang HQ, Xu HX, Sung JJ, Bian ZX*. Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A(1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway. PharmacolBiochemBehav, 2009, 94(1): 88-97.

24.Chen HL, Zhang XJ, Qi SD, Xu HX, Sung JJ, Bian ZX*. Simultaneous determination of glutamate and aspartate in rat periaqueductal gray matter microdialysates by capillary electrophoresis with laser-induced fluorescence. J Chromatogr B AnalytTechnol Biomed Life Sci, 2009, 877(27): 3248-52

25.Chung EK, Bian ZX*, Xu HX, Sung JJ. Neonatal Maternal Separation Increases Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Expression in the Descending Pain Modulatory System. Neurosignals, 2009, 17(3): 213-221.

26.Bian ZX*, Li Z, Huang ZX, Zhang M, Chen HL, Xu HX, Sung JJ. Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients. J Gastroenterol, 2009, 44(7):666-74.

27.Li Z, Zhang XJ, Xu HX, Sung JJ, Bian ZX*. Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats. Eur J Pharmacol., 2009, 606(1-3): 199-204.

28.Qi SD, Tian SL, Xu HX, Sung JJ, Bian ZX*. Quantification of luminally released serotonin in rat proximal colon by capillary electrophoresis with laser-induced fluorescence detection. Anal Bioanal Chem., 2009, 393(8): 2059-66.

29.Zhang XJ, Li Z, Chung EKY, Zhang HQ, Xu HX, Sung JJY, Bian ZX*. Activation of Extracellular signal-regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats. J MolNeurosci., 2009, 37(3): 274-287.

30.Zhang XJ, Li Z, Leung WM, Liu L, Xu HX, Bian ZX*. The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. J Pain., 2008, 9: 497-505.

 

Part II  Clinical Researches

1.Lu L, Zhang XG, Zhong LL, Chen ZX, Li Y, Zheng GQ, Bian ZX. Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis. Sci Rep. 2016 Jan 20;6:19521.

2.Song TJ, Leng HF, Zhong LL, Wu TX, Bian ZX*. CONSORT in China: past development and future direction. Trials. 2015; 16: 243.

3.Xiao HT, Zhong L, Tsang SW, Lin ZS, Bian ZX*. Traditional Chinese medicine formulas for irritable bowel syndrome: from ancient wisdoms to scientific understandings. Am J Chin Med. 2015; 43(1): 1-23.

4.Bian ZX*, Xu H, Lu AP, Lee MS, Cheung CW. Insights of Traditional Chinese Medicine syndrome study: From current status to future prospects, Chin J Integr Med. 2014; 20(5): 326-31

5.Zhong LL, Bian ZX, Gu JH, Zhou X, Tian Y, Mao JC, Chen XJ. Chinese Herbal Medicine (ZiShen Qing) for Mild-to-Moderate Systematic Lupus Erythematosus: A Pilot Prospective, Single-Blinded, Randomized Controlled Study. Evid Based Complement Alternat Med. 2013;2013:327245. doi: 10.1155/2013/327245.

6.Cheng CW, Fu SF, Zhou QH, Wu TX, Shang HC, Tang XD, Liu ZS, Liu J, Lin ZX, Lao L, Lü AP, Zhang BL, Liu BY, Bian ZX*. Extending the CONSORT Statement to moxibustion. J Integr Med, 2013, 11(1): 54-63.

7.Lu AP, Bian ZX, Chen KJ. Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology. Chinese J Integrative Med., 2012, 18(12): 883-90.

8.Cheng CW, Kwok AOL, Bian ZX, Tse DMW. A Cross Sectional Study of Constipation and Laxatives Use in Advanced Cancer Patients: Insights for Revision of Current Practice. Support care Cancer, 2013, 21(1): 149-56.

9.Cheng CW, Kwok AO, Bian ZX*, Tse DMW*. The Quintessence of Traditional Chinese Medicine: Syndrome and Its Distribution among Advanced Cancer Patients with Constipation, Evid.-based Complement Altern. Med., 2012; 739642.

10.Bian ZX*; Chen SL*, Chung CW, Wang J, Xiao HT, Qin HY. Developing new drugs from annals of Chinese medicine. ActaPharmaceuticaSinica B., 2012, 2(1): 1-7.

11.Zeng XX, Bian ZX*, Wu TX, Fu SF, Ziea E, Woon WT. Traditional Chinese Medicine Syndrome Distribution in Chronic Hepatitis B Populations: A Systematic Review. Am J Chin Med., 2011, 39(6): 1061-1074.

12.Bian ZX*, Shang HC. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med., 2011, 154(4):290-1.

13.Bian ZX*, Chang YH, Revised STRICTA as a extending the CONSORT Statement: More items should be involved in the checklist. J AlternComplem Med., 2011, 17(2): 97-8

14.Cheng CW, Bian ZX*, Zhu LX, Wu JC, Sung JJ. Efficacy of a Chinese herbal proprietary medicine (Hemp Seed Pill) for functional constipation. Am J Gastroenterol., 2011, 106(1):120-9

15.Bian ZX*, Cheung CW, Fan Y. Evidence-based Management of Herb-Drug Interaction in Cancer Chemotherapy, Explore (NY., 2010, 6(5): 324-9.

16.Wang L, Cui X, Cheng L, Yuan Q, Li T, Li Y, Deng S, Shang H, Bian ZX. Adverse events to Houttuynia injection: A systematic review. J Evid Based Med., 2010, 3(3): 168-76.

17.Bian ZX*. Wu TX. Legislation for trial registration and data transparency. Trials 2010, 11:64.

18.Bian ZX, Tian HY, Gao L, Shang HC, Wu TX, Li YP, Zhang BL, Song L. Improving reporting of adverse events and adverse drug reactions following injections of Chinese materiamedica, J Evid Based Med., 2010, 5-10.

19.Wu TX, Shang HC, Bian ZX, Zhang JH, Li TQ, Li YP, Zhang BL. Recommendations for reporting adverse drug reactions and adverse events of traditional Chinese medicine. J Evid Based Med., 2010, 11-17.

20.Bian ZX*, Shang HC, Wu TX, Li YP, Zhang BL. Review of adverse reactions to Chinese medicine injections. J Evid Based Med., 2010: 88-94.

21.Cheng CW, Bian ZX*, Wu TX. Systematic review of Chinese herbal medicine for functional constipation. World J Gastroenterol, 2009, 15(39): 4886-95.

22.Wu TX, Li YP, Bian ZX, Liu GJ, Moher D. Randomized trials published in some Chinese journals: how many are randomized? Trials, 2009, 10: 46.

23.Cheng CW, Bian ZX*. How can apples be mixed with oranges? Explore (NY), 2008, 4(6): 379.

24.Bian ZX*, Moher D, Li YP, Wu TX, Dagenais S, Cheng CW, Li J, Li TQ. Appropriately selecting and concisely reporting the outcome measures of randomized controlled trials of traditional Chinese medicine (CONSORT for TCM). J Chin Integr Med., 2008, 6: 771-5.

25.Cheng CW, Bian ZX*, Li YP, Moher D, Wu TX, Dagenais S, Li J, Li TQ. Transparently reporting adverse effects of Traditional Chinese Medicine interventions in randomized controlled trials. J Chin Integr Med., 2008, 6: 881-6.

26. Bian ZX*, Moher D. Clinical Studies and randomized controlled trials in Chinese herbal medicine: A historical and contemporary review. Thieme Almanac, 2008, 5-17.

27.Bian ZX*, Moher D, Li YP, Wu TX, Dagenais S, Cheng CW, Li J, Li TQ. Precise reporting of traditional Chinese medicine interventions in randomized controlled trials. J Chin Integr Med., 2008, 6: 441-447.

28.Wu TX, Li YP, Bian ZX, Li TQ, Li J, Dagenais S, Moher D for the CONSORT for TCM group. Consolidated standards for reporting trials of traditional Chinese medicine (CONSORT for TCM). Chin J Evid-based Med., 2007, 7,625-630.

29.Bian ZX*. Stratification by sex and subgroup is necessary for RCT on IBS. Gut, 2006, 55: 743-4

30.Bian ZX*, Moher D, Dagenais S, Li YP, Wu TX, Liu L, Miao JX, Song L, Zhang HM. Improving the quality of randomized controlled trials in Chinese herbal medicine, part IV: applying a revised CONSORT checklist to measure reporting quality. J Chin Integr Med., 2006, 4: 233-42.

 

 

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