扎根科研,积极投入,广泛合作,专心做事

 
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曾广智

基本情况

姓  名: 曾广智

职  称: 副研究员

学  历: 博士研究生

学  位: 博士 

电子邮箱:gzh_zeng@mail.kib.ac.cn

    曾广智,女,回族,副研究员,博士, 1976年12月生。2000年毕业于中国医科大学药理学专业,获学士学位,2007年获中国科学院昆明植物研究所 植物学博士;2007年至2015年就职于中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室。2015年引进到云南民族大学-香 港浸会大学传统天然药物研发联合实验室工作,主要从事生物方面的研究,以第一作者、共同通讯作者发表论文16篇,参与发表论文40多。

主持和参加的主要科研项目

1)主持完成国家自然科学基金青年科学基金项目《紫菀免疫抑制活性环肽发现、结构改造与作用机制研究》(项目起止年月:2012.01-2014.12)
2)主持完成云南省自然科学基金面上项目《紫菀免疫抑制活性环肽发现、结构改造与作用机制研究》 (项目起止年:2011.01-2014.12)。

3)主持完成植物化学与西部植物资源持续利用国家重点实验室开放课题《中药紫菀环肽的免疫抑制活性及作用机制研究》(项目起止年月:2011.01-2012.12)。

4)主持云南民族大学科研项目《傣药油瓜中抗炎物质的化学与活性机制研究》(项目起止年月:2016.5-2018.4)

主要发表的学术论文

1. Guang-Zhi Zeng, Ning-Hua Tan, Xiao-Jiang Hao, Quan-Zhang Mu, Rong-Tao Li. Natural inhibitors targeting osteoclast-mediated bone resorption. Bioorganic & Medicinal Chemistry Letters, 2006, 16, 6178-6180.

2. Guang-Zhi Zeng, Xu-Lin Pan, Ning-Hua Tan, JiangXiong, Yu-Mei Zhang. Natural biflavones as novel inhibitors of cathepsin B and K. European Journal of Medicinal Chemistry, 2006, 41, 1247-1252.

3. Guang-Zhi Zeng, Ning-Hua Tan, Chang-Jiu Ji, Jun-Ting Fan, Huo-Qiang Huang, Hong-Jin Han, Guang-Biao Zhou. Apoptosis Inducement of Bigelovin from Inula helianthus-aquaticaon Human Leukemia U937 Cells.Phytotherapy. Research, 2009, 23, 885-891.

4. Guang-Zhi Zeng, Jun-Ting Fan, Jun-Ju Xu, Yan Li, Ning-Hua Tan*. Apoptosis induction and G2/M arrest of 2-methyl-1, 3, 6-trihydroxy-9,10-anthraquinone from Rubiayunnanensisin human cervical cancer HeLa cells. Pharmazie, 2013, 68, 293-299.

5. Hui-Min Xu, Guang-Zhi Zeng(共同第一作者), Wen-Bing Zhou, Wen-Jun He, Ning-Hua Tan. AstinsKeP, six new chlorinated cyclopentapeptides from Aster tataricus. Tetrahedron, 2013, 69, 7964-7969.

6. Wen-Bing Zhou, Guang-Zhi Zeng(共同第一作者), Hui-Min Xu, Wen-Jun He, Ning-Hua Tan. Astataricusones A–D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricusL. f. Molecules, 2013, 18, 14585-14596.

7. Wen-Bing Zhou, Guang-Zhi Zeng (共同第一作者), Hui-Min Xu, Wen-Jun He, Yu-Mei Zhang, Ning-Hua Tan. Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus. Fitoterapia, 2014, 93, 98-104.

8. Hong-Jin Han, Ning-Hua Tan*, Guang-Zhi Zeng*(共同通讯作者), Jun-Ting Fan, Huo-Qiang Huang, Chang-Jiu Ji, Rui-RuiJia, Qin-Shi Zhao, Ying-Jun Zhang, Xiao-Jiang Hao, Li-Qin Wang. Natural inhibitors of DNA topoisomerase I with cytotoxicities. Chemistry & Biodiversity, 2008, 5, 1364-1368.

9. Jun-Ting Fan, Bin Kuang, Guang-Zhi Zeng*(共同通讯作者) , Si-Meng Zhao, Chang-Jiu Ji, Yu-Mei Zhang, and Ning-Hua Tan*. Biologically active arborinane-type triterpenoids and anthraquinones from Rubiayunnanensis. Journal of Natural Products, 2011, 74, 2069-2080.

10. Jun-Ju Xu, Jun-Ting Fan, Guang-Zhi Zeng*(共同通讯作者), Ning-Hua Tan*. A new tetracyclic diterpene from Jatropha curcas. Helvetica ChimicaActa, 2011, 94, 842-846.

11. Jun-Ju Xu, Huo-Qiang Huang, Guang-Zhi Zeng*(共同通讯作者), Ning-Hua Tan*. Cytotoxic sesquiterpenes and lignans from Saussureadeltoidea. Fitoterapia, 2012, 83, 1125-1130.

12. Wen-Wen Peng, Guang-Zhi Zeng*(共同通讯作者), Wei-Wu Song, Ning-Hua Tan*. A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavate. Chemistry & Biodiversity, 2013, 10, 1317-1321.

13. Mao-Bo huang, Si-Meng Zhao, Guang-Zhi Zeng*(共同通讯作者), Bin Kuang, Xiao-Qiang Chen, Ning-Hua Tan.Rubischumanins A–C, new cytotoxic cyclopeptides from Rubiaschumanniana. Tetrahedron, 2014, 70, 7627-7631.

14. Si-Meng Zhao, Zhe Wang,Guang-Zhi Zeng,* (共同通讯作者)Wei-Wu Song,Xiao-Qiang Chen,Xiao-Nian Li,Ning-Hua Tan*. New Cytotoxic Naphthohydroquinone Dimers from Rubiaalata. Organic Letters, 2014, 16, 5576-5579.

15. 曾广智,黄火强,谭宁华,嵇长久,潘蓄林。碳酸酐酶Ⅱ及其抑制剂研究进展。云南植物研究, 2006, 28, 543-552.

16. 曾广智,谭宁华,贾锐锐,潘蓄林。组织蛋白酶及其抑制剂研究进展。云南植物研究, 2005, 27, 337-354.

17. He Yan, Xu-Lin Pan, Ning-Hua Tan*, Jun-Ting Fan, Guang-Zhi Zeng, Hong-Jin Han. 2D- and 3D-QSAR studies on 54 anti-tumor Rubiaceae-type cyclopeptides. European Journal of Medicinal Chemistry, 2009, 44, 3425-3432.

18. Jun-Ju Xu, Ning-Hua Tan*, Yi-Shan Chen, Xu-Lin Pan, Guang-Zhi Zeng, Hong-Jin Han, Chang-Jiu Ji, Mei-Ju Zhu. Three unusual new sesquiterpenes from Alpiniaoxyphylla. Helvetica ChimicaActa, 2009, 92, 1621-1625.

19. Yu-Mei Zhang, Ning-Hua Tan*, Guang-Zhi Zeng, Abiodun Humphrey Adebayo, Chang-Jiu Ji. A new norlignan fromTaxodiumascendens. Fitoterapia, 2009, 80, 361-363.

20. Jun-Ting Fan, Jia Su, Yan-Min Peng, Yan Li, Jia Li, Yu-Bo Zhou, Guang-Zhi Zeng, He Yan, Ning-Hua Tan*. Rubiyunnanins C–H, cytotoxic cyclic hexapeptides from Rubiayunnanensisinhibiting nitric oxide production and NF-κB activation. Bioorganic & Medicinal Chemistry, 2010, 18, 8226-8234.

21. Jun-Ting Fan, Yi-Shan Chen, Wen-Yan Xu, Liangcheng Du, Guang-Zhi Zeng, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubiayunnanensis. Tetrahedron Letters, 2010, 51, 6810-6813.

22. M. Zhu, N. Tan*, H. Zhu, G. Zeng, W. He, B. Yu, X. Chen. Anti-sports anaemia effects of verbascoside and martynoside in mice. International Journal of Sports Medicine,2010, 31, 537-541.

23. Grace GL Yue, Jun-Ting Fan, Julia KM Lee, Guang-Zhi Zeng, Tina WF Ho, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara BS Lau*. Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial Cells. British Journal of Pharmacology, 2011, 164, 1883-1898.

24. Wen-Jun He, Lai Yue Chan, Guang-Zhi Zeng, Norelle L. Daly, David J. Craikb*, Ning-Hua Tan*. Isolation and characterization of cytotoxic cyclotides from Viola philippica. Peptides, 2011, 32, 1719-1723.

25. Yan Shen, Qiong Luo, Hui-Min Xu, Fang-Yuan Gong, Xiao-Bin Zhou, Yang Sun, Xue-Feng Wu, Wen Liu, Guang-Zhi Zeng, Ning-Hua Tan*, Qiang Xu*. Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis. Biochemical Pharmacology, 2011, 82, 260-268.

26. Wen-Jun He, Zhao-Hui Fu, Hong-Jin Han, He Yan, Guang-Zhi Zeng, Chang-Jiu Ji, Hong-Biao Chu, Yu-Mei Zhang*, Ning-Hua Tan*. Benzoic acid allopyranosides and lignan glycosides from the twigs of Keteleeriaevelyniana. Zeitschriftf¨urNaturforschung, 2011, 66b, 733-739.

27. Chang-Jiu Ji, Guang-Zhi Zeng, Jing Han, Wen-Jun He, Yu-Mei Zhang, Ning-Hua Tan*. Zizimauritic acids A–C, three novel nortriterpenes from Ziziphusmauritiana. Bioorganic & Medicinal Chemistry Letters, 2012, 22, 6377-6380.

28. Wen-Jun He, Zhao-Hui Fu, Guang-Zhi Zeng, Yu-Mei Zhang*, Hong-Jin Han, He Yan,Chang-Jiu Ji, Hong-Biao Chu, Ning-Hua Tan*. Terpene and lignan glycosides from the twigs and leaves of an endangered conifer, Cathayaargyrophylla. Phytochemistry, 2012, 83, 63-69.

29.  Jing-Lei Liu, Guang-Zhi Zeng, Xiao-Li Liu, Yong-Qiang Liu, Zhong-Guo Hu,

Ying Liu, Ning-Hua Tan, Guang-Biao Zhou. Small compound bigelovin exerts

inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells. Cancer

Science, 2013, 104, 1697-1704.

 

申请和授权部分专利

1) 水朝阳悬覆花提取物,以其为有效成分的抗肿瘤药物及其制备方法和应用(专利号: ZL 2010 1 0291812.8)。
2) 茜草科类型环肽,以其为活性成分的药物组合物,其制备方法和应用(专利号:ZL 2010 1 0232742.9)。
3) 茜草科类型环肽及其药物组合物和应用(专利号:ZL 2012 1 0306178.X)

4)菊科类型环肽,以其为活性成分的免疫抑制药物及其制备方法和应用(专利号:ZL2011 1 0039063.4)。

5)以黄皮属植物中的咔唑生物碱为抗肿瘤活性成分的药物组合物及其制备方法与应用(专利号:ZL201310005484.4)。

6)黄皮属植物中的咔唑生物碱,以其为抗肿瘤活性成分的药物组合物,其制备方法和应用(专利号:ZL 201310005483.X)。

7)紫菀酮型三萜及其药物组合物和其制备方法与应用(专利公布号:CN103145792A)

8)醌类化合物及其制备方法与其用作为杀线虫农药(专利公布号:CN104447265A)

9)茜草科类型环肽制备方法及其用作为Hippo-YAP信号通路抑制剂(专利公布号:CN104193808A)

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