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吴疆

基本情况

姓  名: 吴疆

职  称: 讲师

学  历: 博士研究生

学  位: 博士 

电子邮箱:wujiang@lzu.edu.cn

工作单位:兰州大学

    吴疆,男,汉族,讲师,博士。 1981年8月生。2004年毕业于兰州大学,获学士学位,2006年毕业于兰州大学化学化工学院,获得硕士学 位,2011年毕业于美国佐治亚州立大学,获博士学位;2012年至今在兰州大学化学化工学院从事科研教育工作,主要研究方向为多肽合成及药物分子设计。 2015年与云南民族大学-香港浸会大学传统天然药物研发联合实验室合作,以第一作者、共同通讯作者发表论文30多篇。

一 主持参与项目

1)国家自然科学基金青年科学基金项目(跨膜多肽共价修饰的稀土配合物的设计、合成及其在生物荧光成像中的应用研究)项目编号:21201091,执行年限:2013.01-2015.12。

2)教育部留学回国基金:组蛋白乙酰化酶Tip60小分子抑制剂高通量筛选方法研究 。

4)功能有机分子国家重点实验室开放基金。

5)大学生国家创新创业基金。

6)四种臭椿属植物中具有抗植物病原真菌活性的苦木素类化合物的发现与研究(项目编号:31470421 ,执行年限:2015.01-2018.12 80万, 2/10;国家自然科学基金面上项目)。

7)基于多尺度分子模拟技术和复杂网络分析的丙型肝炎病毒耐药性机理研究及耐药性预测模型的构建 (项目编号:21475054  ,执行年限:2015.01-2018.12 86万;国家自然科学基金面上项目)。

8)多功能稀土配合物光-磁纳米探针构筑及多模式成像和药物控释研究(项目编号:21471071,执行年限:2015.01-2018.12 90万;国家自然科学基金面上项目)。

主要发表的学术论文

1. Wang, Peng; Wu, Jiang; Zhou, Panpan. A novel peptide-based fluorescent chemosensor for measuring zinc ions using different excitation wavelengths and application in live cell imaging.Journal of Materials Chemistry,2015, 3, 3617-3624 .

2. Wang, Peng; Wu, Jiang; Liu, Lixuan; et al. A peptide-based fluorescent chemosensor for measuring cadmium ions in aqueous solutions and live cells. Dalton2015, 44, 18057-18064.

3. Wang, Peng; Liu, Lixuan; Zhou, Panpan; Wu, Jiang,et al. A peptide-based fluorescent chemosensor for multianalyte detection.Biosensors & Bioelectronics2015, 72, 80-86 .

4. Gu, Jin-Zhong; Cui, Yan-Hui;Wu, Jiang; et al. A series of mixed-ligand 2D and 3D coordination polymers assembled from a novel multifunctional pyridine-tricarboxylate building block: hydrothermal syntheses, structural and topological diversity, andmagnetic and luminescent properties.Rsc Advances2015, 5,78889-78901 .

5. Yang, Y.; Wu, J.; Ma, J.; et al.  Chemical Composition and Antimicrobial Activity of the Essential Oil from Artemisia carvifolia Leaves.  Chemistry of Natural, 2015, 51, 161-163.

6. Ngo, Liza; Wu, Jiang; Yang, Chao; et al. Effective Quenchers Are Required to Eliminate the Interference of Substrate: Cofactor Binding in the HAT Scintillation Proximity Assay.Assay and drug development, 2015, 13, 210-20.

7. Cui, Yan-Hui; Wu, Jiang; Kirillov, Alexander M.; et al. Exploring 5-fluoronicotinic acid as a versatile building block for the generation of topologically diverse metal-organic and supramolecular Ni, Co, and Cd networks.  Rsc Advances2015, 51, 10400-10411.

8. Li, Yiran; Wu, Jiang; Jin, Xiaojie; et al. A bimodal multianalyte simple molecule chemosensor for Mg2+, Zn2+, and Co2+. Dalton Transactions , 2014, 43, 1881-1887.

9. Gu, Jin-Zhong; Wu, Jiang; Kirillov, Alexander M.; et al. Assembling supramolecular networks by halogen bonding in coordination polymers driven by 5-bromonicotinic acid. Journal of Solid State2014, 213, 256-267.

10. Liu, Rui-ke; Yang, Yang; Wu, Jiang; et al. Chemical Composition and Antimicrobial Activity of the Essential OIL of Ajania przewalskii.Chemistry of Natural2014, 50, 370-372 .

11. Han, Shuai; Liu, Feng; Wu, Jiang; et al. Targeting of fluorescent palygorskite polyethyleneimine nanocomposite to cancer cells. Applied Clay Science2014,101,567-573.

12. Gu, Jin-Zhong; Wu, Jiang; Lv, Dong-Yu; et al.  Lanthanide coordination polymers based on 5-(2 '-carboxylphenyl) nicotinate: syntheses, structure diversity, dehydration/hydration, luminescence and magnetic properties.Dalton2013, 42, 4822-4830 .

13. Gu, Jin-Zhong; Kirillov, Alexander M.; Wu, Jiang; et al. Synthesis, structural versatility, luminescent and magnetic properties of a series of coordination polymers constructed from biphenyl-2,4,4 '-tricarboxylate and different N-donor ligands.Crystengcomm2013, 15,  10287-10303 .

14 .Ghizzoni, Massimo; Wu, Jiang; Gao, Tielong; et al.  6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site.European Journal of Medicinal2012, 47, 337-344.

15. Wang, Jianwei; Wu, Jiang; Chen, Yanmei; et al. A small-molecular europium complex with anion sensing sensitivity.Dalton,2012,41, 12936-12941 .

16. Yang, Chao; Wu, Jiang; Sinha, Sarmistha H.; et al. Autoacetylation of the MYST Lysine Acetyltransferase MOF Protein.Journal ofBiological,2012,287,34917-34926.

17. Yang, Chao; Wu, Jiang; Zheng, Y. George. Function of the Active Site Lysine Autoacetylation in Tip60 Catalysis. Plos One , 2012, 7.

18. Wu, Jiang; Xie, Nan; Feng, You; et al.  Scintillation Proximity Assay of Arginine Methylation.Journal of Biomolecular2012,17, 237-244.

19Wu, Jiang; Wang, Juxian; Li, Minyong; et al. Small molecule inhibitors of histone acetyltransferase Tip60.Bioorganic2014, 39, 53-58.

20Wu, Jiang; Zheng, Yujun George. Synthesis of H4 pantetheine adducts for histone acetyltransferase inhibition.Heterocyclic2010, 16, 4-6 .

21. Wu, Jiang; Xie, Nan; Wu, Zhikun; et al.  BisubstrateInhibitors of the MYST HATs Esa1 and Tip60.Bioorganic & Medicinal2009, 17, 1381-1386.

22. Feng, You; Xie, Nan; Wu, Jiang; et al.  Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach. Biochemical and Biophysical Research2009, 379, 567-572.

23. Wu, Jiang; Zheng, Yujun George. BIOL 204-Fluorescent reporter assays for histone acetyltransferases.Abstracts of Papers of the American Chemical2008.

24. Zheng, Yujun George; Wu, Jiang; Chen, Ziyue; et al. Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy.Medicinal Research2008, 28, 645-687.

25. Wu, Jiang; Zheng, Yujun George.  Fluorescent reporters of the histone acetyltransferase. Analytical2008, 380, 106-110 .

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